Development of an LC-NMR System Using a Diode Array Detector and a Charged Aerosol Detector

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  • ダイオードアレイ検出器と荷電化粒子検出器を用いたLC-NMRシステムの構築
  • ダイオードアレイ ケンシュツキ ト カデンカ リュウシ ケンシュツキ オ モチイタ LC-NMR システム ノ コウチク

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<p>Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for structure determination. However, NMR spectra sometimes suffer from severe signal overlaps. To avoid such signal overlaps, LC-DAD-NMR systems have been used. These systems have enabled the separation of components on a column before NMR detection. However, DAD detection alone is insufficient when the sample does not contain chromophores. To increase the detection coverage, we used a corona charged aerosol detector (CAD) that responded to analytes independent of their physical/chemical characteristics. The established LC-DAD/CAD NMR system was evaluated. Its calculated detection and quantitation limits were 0.25 and 1.0 μg/peak, respectively. This system was used to analyze rubus extract. Along with glucose and fructose, a small amount of rubusoside was detected by corona CAD and identified by NMR without needing a chromophore.</p>

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  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 69 (3), 151-155, 2020-03-05

    The Japan Society for Analytical Chemistry

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