Efficacy and safety of 12-week sofosbuvir/velpatasvir treatment of patients with decompensated liver cirrhosis caused by hepatitis C virus infection

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  • Takaoka Yoshinari
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Miura Kouichi
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Morimoto Naoki
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Kakizaki Satoru
    Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine
  • Ikegami Tadashi
    Department of Gastroenterology, Ibaraki Medical Center, Tokyo Medical University
  • Ueno Takashi
    Department of Internal Medicine, Isesaki Municipal Hospital
  • Arai Hirotaka
    Department of Gastroenterology, Maebashi Red Cross Hospital
  • Hatanaka Takeshi
    Department of Gastroenterology, Gunma Saiseikai Maebashi Hospital
  • Tahara Toshiyuki
    Department of Gastroenterology, Saiseikai Utsunomiya Hospital
  • Murohisa Toshimitsu
    Department of Gastroenterology, Ashikaga Red Cross Hospital
  • Namikawa Masashi
    Department of Internal Medicine, Kiryu Kosei General Hospital
  • Naganuma Atsushi
    Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
  • Ohtake Takaaki
    Department of Gastroenterology, International University of Health and Welfare Hospital
  • Horiuchi Katsuhiko
    Department of Gastroenterology, Gunma Chuo Hospital, Japan Community Health care Organization
  • Asano Takeharu
    Department of Gastroenterology, Saitama Medical Center, Jichi Medical University
  • Kamoshida Toshiro
    Department of Gastroenterology, Hitachi General Hospital
  • Tano Shigeo
    Department of Gastroenterology, Shin-Oyama City Hospital
  • Fukaya Yukimura
    Department of Internal Medicine, Nasu Minami Hospital
  • Kosone Takashi
    Department of Gastroenterology and Hepatology, Kusunoki Hospital
  • Watanabe Shunji
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Tsukui Mamiko
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Hirosawa Takuya
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Nomoto Hiroaki
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Goka Rie
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Maeda Hiroshi
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Sato Naoto
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Isoda Norio
    Department of Medicine, Division of Gastroenterology, Jichi Medical University
  • Yamamoto Hironori
    Department of Medicine, Division of Gastroenterology, Jichi Medical University

Bibliographic Information

Other Title
  • C型非代償性肝硬変に対するソフォスブビル/ベルパタスビル12週治療の有効性と安全性
  • Cガタ ヒダイショウセイ カンコウヘン ニ タイスル ソフォスブビル/ベルパタスビル 12シュウ チリョウ ノ ユウコウセイ ト アンゼンセイ

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Abstract

<p>In this multicenter study, we evaluated the efficacy and safety of 12-week sofosbuvir/velpatasvir (SOF/VEL) treatment. We enrolled 43 consecutive patients with decompensated cirrhosis caused by hepatitis C virus (HCV) infection, 72% and 28% of them were positive for genotype 1 and 2, respectively. At baseline, 79% of the patients were Child-Pugh (CP) class B and 19% were CP class C. All patients completed the 12-week SOF/VEL treatment without any severe adverse events. At post-treatment week 12, 41 patients achieved a sustained virological response (95%), and 21 showed improvement in CP class. The remaining two patients were lost to follow-up. Encephalopathy was a frequent adverse event (16%), but was well-controlled by outpatient management. In conclusion, 12-week SOF/VEL treatment is effective and safe for patients with decompensated cirrhosis caused by HCV infection.</p>

Journal

  • Kanzo

    Kanzo 61 (5), 276-278, 2020-05-01

    The Japan Society of Hepatology

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