Two Cases of Apalutamide-induced Lichenoid Drug Rash

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  • アパルタミドによる苔癬型薬疹の2例
  • 症例報告 アパルタミドによる苔癬型薬疹の2例
  • ショウレイ ホウコク アパルタミド ニ ヨル タイセンガタヤクシン ノ 2レイ

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Abstract

<p>Apalutamide, an oral androgen receptor antagonist, has been used to metastatic castration-sensitive prostate cancer from 2019 in Japan. It has been known that treatment with apalutamide frequently develops skin rash, which occurs at 2-3 months after starting the therapy. Although skin rash was most commonly described as maculo-papular rash, the details about skin manifestations have been unclear. Two Japanese men developed widespread, pruritic, erythematous scaly rash on the trunk and the extremities with peripheral eosinophilia after 6 and 9 weeks after starting therapy with apalutamide. Histological examination showed interface dermatitis with vacuolar change, exocytosis of lymphocytes, and Civatte bodies. After the discontinuation of apalutamide, the erythema gradually improved. Apalutamide should be taken in consideration as a causative drug of lichenoid drug rash.</p>

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