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- Miyabe Suguru
- R&D Headquarters, Isehan Co., Ltd.
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- Yonemura Hiroki
- R&D Headquarters, Isehan Co., Ltd.
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- Takeda Hirohumi
- R&D Headquarters, Isehan Co., Ltd.
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- Suzuki Koji
- R&D Headquarters, Isehan Co., Ltd.
Bibliographic Information
- Other Title
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- セルフタンニング剤における着色強度の向上
- セルフタンニングザイ ニ オケル チャクショク キョウド ノ コウジョウ
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Description
<p>Dihydroxyacetone (DHA) is used as the main agent of self-tanning formulations. However, it is difficult to formulate DHA with high content because of its very high reactivity and instability, and it is known that coloring strength has been increased by using polyhydric alcohol in combination up to now. In this study, we investigated improving coloring strength in vitro and in vivo using water-soluble components including polyhydric alcohol. As a result, Methyl gluceth-10 (MG-10) was most effective in vitro. In contrast, MG-10 alone was the most ineffective in vivo. However, it was revealed that the coloring strength was improved by mixing with ethanol. We thought that ethanol distrubs the lamellar structure in the stratum corneum, shakes the intercellular lipid structure, and makes skin permeation easier, whereas the molecular weight was so large that it could not penetrate the skin alone. We focused on the polyethylene glycol (PEG) structure in MG-10, and changed the PEG chain length in vitro to confirm the coloring effect. Furthermore, as an additional test, the number of oxygen atoms in the solution was adjusted to PEG-40 and made constant, and the coloring effect was confirmed. As a result, in the test in which the number of moles of PEG was constant, it was found that the coloring effect was improved as the chain length of PEG became longer. On the other hand, in the test in which the number of oxygen atoms in the solution was constant, the same absorbance was obtained uniformly. From these results, it was thought that the oxygen in the PEG chain contributed to the coloring effect. Furthermore, MALDI/MS measurement and FT-IR measurement suggested that oxygen atoms in the PEG chain plays the role of mediator via its hydrogen bond with the amino acid and DHA.</p>
Journal
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- Journal of Society of Cosmetic Chemists of Japan
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Journal of Society of Cosmetic Chemists of Japan 54 (2), 160-168, 2020-06-20
The Society of Cosmetic Chemists of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390285300169114112
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- NII Article ID
- 130007863956
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- NII Book ID
- AN00101606
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- ISSN
- 18844146
- 03875253
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- NDL BIB ID
- 030527770
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed