4-Aminopyridine, a Voltage-Gated K⁺ Channel Inhibitor, Attenuates Nitric Oxide-Mediated Vasodilation of Retinal Arterioles in Rats

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  • Mori Asami
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Namekawa Ryo
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Sakamoto Kenji
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Ishii Kunio
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Nakahara Tsutomu
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences

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  • 4-Aminopyridine, a Voltage-Gated K<sup>+</sup> Channel Inhibitor, Attenuates Nitric Oxide-Mediated Vasodilation of Retinal Arterioles in Rats

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<p>Nitric oxide (NO) is an important regulator of the retinal blood flow. The present study aimed to determine the role of voltage-gated K+ (KV) channels and ATP-sensitive K+ (KATP) channels in NO-mediated vasodilation of retinal arterioles in rats. In vivo, the retinal vasodilator responses were assessed by measuring changes in the diameter of retinal arterioles from ocular fundus images. Intravitreal injection of 4-aminopyridine (a KV channel inhibitor), but not glibenclamide (a KATP channel blocker), significantly attenuated the retinal vasodilator response to the NO donor (±)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (NOR3). Intravitreal injection of indomethacin (a non-selective cyclooxygenase inhibitor) also reduced the NOR3-induced retinal vasodilator response. The combination of 4-aminopyridine and indomethacin produced a greater reduction in the NOR3-induced response than either agent alone. 4-Aminopyridine had no significant effect on pinacidil (a KATP channel opener)-induced response. These results suggest that the vasodilatory effects of NO are mediated, at least in part, through the activation of 4-aminopyridine-sensitive KV channels in the retinal arterioles of rats. NO exerts its dilatory effect on the retinal vasculature of rats through at least two mechanisms, activation of the KV channels and enhancement of prostaglandin production.</p>

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