Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis
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- Oka Aiko
- Department of Otorhinolaryngology, International University of Health and Welfare Graduate School of Medicine
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- Ninomiya Takahiro
- Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
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- Fujiwara Tazuko
- Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Takao Soshi
- Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Sato Yasuharu
- Division of Pathophysiology, Okayama University Graduate School of Health Sciences
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- Gion Yuka
- Division of Pathophysiology, Okayama University Graduate School of Health Sciences
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- Minoura Akira
- Department of Hygiene, Public Health and Preventive Medicine, Showa University School of Medicine
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- Haruna Shin-ichi
- Department of Otorhinolaryngology, Head & Neck Surgery, Dokkyo Medical University
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- Yoshida Naohiro
- Department of Otolaryngology, Jichi Medical University Saitama Medical Center
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- Sakuma Yasunori
- Department of Otorhinolaryngology, Yokohama City Medical Center
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- Izuhara Kenji
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
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- Ono Junya
- Shino-Test Co., Ltd.
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- Taniguchi Masami
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Haruna Takenori
- Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Higaki Takaya
- Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Kariya Shin
- Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Koyama Takahisa
- Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Takabayashi Tetsuji
- Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
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- Imoto Yoshimasa
- Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
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- Sakashita Masafumi
- Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
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- Kidoguchi Masanori
- Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
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- Nishizaki Kazunori
- Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Fujieda Shigeharu
- Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
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- Okano Mitsuhiro
- Department of Otorhinolaryngology, International University of Health and Welfare Graduate School of Medicine Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Description
<p>Background: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology of CRS is desirable in a clinical setting. As IgG4 production is regulated by type 2 cytokines, we sought to determine whether serum IgG4 levels can be used as a biomarker for CRS.</p><p>Methods: Association between the serum IgG4 levels and clinicopathological factors was analyzed in 336 CRS patients. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value of serum IgG4 levels that can be used to predict the post-operative recurrence.</p><p>Results: Serum IgG4 levels were significantly higher in patients with moderate to severe ECRS versus those with non to mild ECRS. The levels were also significantly higher in asthmatic patients and patients exhibiting recurrence after surgery compared to controls. ROC analysis determined that the best cut-off value for the serum IgG4 level to predict the post-operative recurrence was 95 mg/dL. The corresponding sensitivity and specificity were 39.7% and 80.5%, respectively. When we combined the two cut-off values for the serum IgG4 and periostin, patients with high serum levels of either IgG4 or periostin exhibited a high post-operative recurrence (OR: 3.95) as compared to patients having low serum levels of both IgG4 and periostin.</p><p>Conclusions: The present results demonstrate that the serum IgG4 level is associated with disease severity and post-operative course in CRS. In particular, the combination of serum IgG4 and periostin could be a novel biomarker that predicts post-operative recurrence.</p>
Journal
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- Allergology International
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Allergology International 69 (3), 417-423, 2020
Japanese Society of Allergology
