Treatment with the traditional Chinese medicine <i>BuYang HuanWu Tang</i> induces alterations that normalize the microbiome in ASD patients

DOI Web Site 参考文献37件
  • ZHANG Yuping
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China School of Medicine, Nanchang University, Nanchang 330006, P. R. China Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang 330006, P. R. China
  • HU Niya
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China
  • CAI Qinming
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China
  • ZHANG Feng
    Institute of Translational Medicine, Nanchang University, Nanchang, 330031, P. R. China
  • ZOU Jun
    Jiangxi Provincial Children’s Hospital, Nanchang, 330006, P. R. China
  • LIU Yanling
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China
  • WEI Dandan
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China
  • ZHU Qing
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China
  • CHEN Kaisen
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China
  • ZENG Lingbing
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China
  • HUANG Xiaotian
    Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, P. R. China School of Medicine, Nanchang University, Nanchang 330006, P. R. China

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<p>Autism spectrum disorders (ASDs) are prevalent neurobiological conditions with complicated causes worldwide. Increasing researcher awareness of ASD and accumulated evidence suggest that the development of ASD may be strongly linked to the dysbiosis of the gut microbiota. In addition, most of the current studies have compared autistic children and neurotypical children or have compared ASD patients before and after antibiotic treatment. Treatment of autism with traditional Chinese medicine (TCM) has increasingly been promoted, but the relationship between its efficacy and intestinal flora has rarely been reported. Under the premise that treatment with the TCM BuYang HuanWu Tang is effective, we conducted a comparative bioinformatics analysis to identify the overall changes in gut microbiota in relation to ASD by comparing the intestinal flora before and after treatment with TCM and contrasting the intestinal flora with that of healthy controls. At the phylum level, Proteobacteria showed a significant increase in children with ASD, which may be a signature of dysbiosis in the gut microbiota. At the genus level, Blautia, Coprococcus 1, the Lachnospiraceae family, and the Ruminococcaceae family were found at the lowest levels of relative abundance in children with ASD, whereas the abundances of Escherichia-Shigella, Klebsiella, and Flavonifractor were significantly increased compared with those in the healthy control group. In sum, this study characterized the alterations of the intestinal microbiome in children with ASD and its normalization after TCM treatment (TCMT), which may provide novel insights into the diagnosis and therapy of ASD.</p>

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