Four-week repeated dose oral toxicity study of gum ghatti in rats

DOI Web Site 参考文献4件
  • Kawahara Ryo
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
  • Watanabe Kenichiro
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
  • Yamane Rina
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
  • Yasui Hideki
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
  • Kikugawa Nao
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
  • Mori Naoko
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
  • Akiyama Ryosuke
    Product Design Laboratory Medical Foods Research Institute OS-1 Division, Otsuka Pharmaceutical Factory, Inc.
  • Matsubara Takeshi
    Product Design Laboratory Medical Foods Research Institute OS-1 Division, Otsuka Pharmaceutical Factory, Inc.
  • Harada Miwa
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
  • Kaneda Shinya
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.

この論文をさがす

説明

<p>We investigated the potential toxicity of gum ghatti, which is added to food for emulsifying, thickening, and stabilizing, after 4 weeks of repeated oral administration at a dose of 8000 mg/kg/day to male and female SD rats. Although food consumption was significantly reduced in males in the gum ghatti group compared with those in the distilled water group from Day 18 onwards, the change was minor, there was no pathological evidence of digestive tract abnormalities, and there were no significant changes in body weight; therefore, the change in food consumption was judged to be of no toxicological significance. Hematology and blood biochemistry revealed statistically significant differences in some parameters between the gum ghatti group and the distilled water group. These changes were all within the normal range of physiological variation and therefore were not considered to represent the effects of gum ghatti. In addition, general signs, body weight, and pathology showed no changes in either sex attributable to gum ghatti. Thus, all changes observed were of no toxicological significance and within the normal range of physiological variation, suggesting gum ghatti has no toxic effects in rats.</p>

収録刊行物

参考文献 (4)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ