A rapid measurement of plasma concentration of a molecular-targeted drugs with diamond sensor.
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- Ogata Genki
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Saiki Takuro
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan Department of Medical Oncology, Niigata University School of Medicine, Niigata, Japan
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- Sawamura Sheishiro
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Razvina Olga
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Watanabe Kota
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Kato Rito
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
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- Asai Kai
- Department of Chemistry, Faculty of Science and Technology, Keio Univ, Yokohama, Japan
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- Hanawa Ai
- Department of Chemistry, Faculty of Science and Technology, Keio Univ, Yokohama, Japan
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- Matsumoto Yoshifumi
- Department of Medical Oncology, Niigata University School of Medicine, Niigata, Japan
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- Saijo Yasuo
- Department of Medical Oncology, Niigata University School of Medicine, Niigata, Japan
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- Einaga Yasuaki
- Department of Chemistry, Faculty of Science and Technology, Keio Univ, Yokohama, Japan
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- Hibino Hiroshi
- Department of Molecular Physiology, Niigata University School of Medicine, Niigata, Japan
Bibliographic Information
- Other Title
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- ダイヤモンドセンサを用いた血漿中分子標的薬迅速測定法の開発
Description
<p>Molecular-targeted anticancer drugs elicit less toxicity than conventional reagents. Yet, patients often suffer from severe adverse effects. The reason is "fixed dosage" administration of the drug to all the patients regardless of their body size and complications; because of this strategy, the plasma concentration seems to occasionally exceed the therapeutic window. Although frequent measurement of the drug level at a clinical site is a solution, currently available methods are unsuitable. To overcome this shortcoming, in this study we developed a procedure with an electrochemical sensor composed of conductive diamond, which yields more stable reactions than conventional materials. When guinea-pig plasma mixed with imatinib, lenvatinib, or pazopanib were tested, the sensor detected a clinically relevant concentration. Time and sample amount necessary for each series of the measurement was <1 min and 100 μL, respectively. This method may enable therapeutic drug monitoring of molecular-targeted drugs and accelerate tailored medicine for cancer.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering Annual58 (Abstract), 286-286, 2020
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390285300180911872
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- NII Article ID
- 130007884952
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed