Expression of Ganglioside Disialosyl Globopentaosyl Ceramide in Prostate Biopsy Specimens as a Predictive Marker for Recurrence after Radical Prostatectomy

  • Sato Masahiko
    Department of Urology, Tohoku University Graduate School of Medicine
  • Shimada Shuichi
    Department of Urology, Tohoku University Graduate School of Medicine
  • Watanabe Mika
    Department of Pathology, Tohoku University Graduate School of Medicine
  • Kawasaki Yoshihide
    Department of Urology, Tohoku University Graduate School of Medicine
  • Sato Tomonori
    Department of Urology, Tohoku University Graduate School of Medicine
  • Morozumi Kento
    Department of Urology, Tohoku University Graduate School of Medicine
  • Mitsuzuka Koji
    Department of Urology, Tohoku University Graduate School of Medicine
  • Ito Akihiro
    Department of Urology, Tohoku University Graduate School of Medicine

Search this article

Description

<p>Carbohydrate antigens are associated with carcinogenesis, cancer invasion, and metastasis and their expression reflect biological activities of various cancers. We previously reported that expression of disialosyl globopentaosyl ceramide (DSGb5), one of carbohydrate antigens, in radical prostatectomy specimens independently predicted biochemical recurrence (i.e., elevating serum prostate specific antigen without recurrent lesions in the image) after radical prostatectomy. However, it is important to evaluate the prognosis at the diagnosis. In this study we investigated DSGb5 expression in prostate biopsy specimens to develop a novel biomarker for providing appropriate management. Between 2005 and 2011, patients who underwent both prostate biopsy and radical prostatectomy in our institution were included. The median follow-up period was 88 months. DSGb5 expression was assessed by immunohistochemical staining and defined 116 patients as high DSGb5 expression (42 patients) or low DSGb5 expression (74 patients). High DSGb5 expression was significantly associated with lymphovascular invasion in radical prostatectomy specimens on both univariate and multivariable analyses (p = 0.028, 0.027). On multivariable analysis, Gleason Score in prostatectomy specimen, positive resection margin, and DSGb5 expression in the biopsy specimen were independently associated with biochemical recurrence-free survival following radical prostatectomy (p = 0.004, 0.008, 0.024). When targeting only patients with negative resection margin, DSGb5 expression was significantly associated with biochemical recurrence-free survival on both univariate and multivariable analyses (p = 0.006, 0.007). DSGb5 expression in prostate biopsy specimens is predictive of lymphovascular invasion and biochemical recurrence-free survival following radical prostatectomy. DSGb5 is a potential biomarker for preoperatively predicting oncological outcomes of prostate cancer.</p>

Journal

References(11)*help

See more

Related Projects

See more

Details 詳細情報について

Report a problem

Back to top