Inhibition of HIV-1 Reverse Transcriptase Activity by the Extracts of Indian Plants
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- Ishizuka Keiko
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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- Tsutsumi Yuto
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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- Baba Misato
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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- Biyani Radhika
- School of Materials Science, Japan Advanced Institute of Science and Technology
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- Wei Meng Chen
- School of Biological Science, Nanyang Technological University
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- Biyani Manish
- School of Materials Science, Japan Advanced Institute of Science and Technology Department of Biotechnology, Biyani Girls College
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- Jaiswal Jyotsna
- Department of Biochemistry, University of Allahabad
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- Sharma Bechan
- Department of Biochemistry, University of Allahabad
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- Kojima Kenji
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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- Takita Teisuke
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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- Yasukawa Kiyoshi
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Description
As the currently available therapies for HIV-1 have high costs and are associated with the appearance of multi-drug resistant HIV-1 strains, the Indian traditional medicine system Ayurveda may provide useful alternatives. In this study, we screened the inhibitory activities of various extracts of five Indian plants for inhibitory effects on HIV-1 reverse transcriptase (RT). Water extracts of the leaves of Argemone mexicana strongly inhibited the DNA polymerase activity of HIV1 RT, which indicated that they contained substances with inhibitor activity. Neither heat treatment at 100ºC nor proteinase K treatment of the extracts abolished the inhibitory activity, suggesting that the inhibitory substance was an organic compound rather than a protein.
Journal
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- Journal of Biological Macromolecules
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Journal of Biological Macromolecules 20 (1), 17-22, 2020
Japan Science Society of Biological Macromolecules