Systemic Wild-type Amyloid Transthyretin Amyloidosis in Carpal Tunnel Syndrome in Men

DOI Web Site 12 References
  • Sato Daiki
    Department of Spinal Surgery, Kameda General Hospital Department of Neurosurgery, Tokyo Women's Medical University
  • Yuzurihara Masahito
    Department of Spinal Surgery, Kameda General Hospital
  • Takebayashi Kento
    Department of Spinal Surgery, Kameda General Hospital Department of Neurosurgery, Tokyo Women's Medical University
  • Kubota Motoo
    Department of Spinal Surgery, Kameda General Hospital
  • Tachibana Shigekuni
    Department of Spinal Surgery, Kameda General Hospital
  • Kawamata Takakazu
    Department of Neurosurgery, Tokyo Women's Medical University

Bibliographic Information

Other Title
  • 男性手根管症候群における全身性野生型トランスサイレチンアミロイドーシスの検討

Abstract

<p>  Carpal tunnel syndrome is the most common initial manifestation of systemic wild-type amyloid transthyretin (ATTR) amyloidosis, a systemic and lethal form of amyloidosis, which can alternatively present as a focal disease. Herein, we present a case series of six men who underwent the removal of a portion of the transverse carpal ligament during carpal tunnel release surgery and were diagnosed with ATTR amyloidosis among a cohort of 38 cases. In addition, one of the six patients with ATTR amyloidosis had cardiac and gastric amyloidosis. Extraction of part of a ligament during carpal tunnel release surgery is a straightforward procedure that can help diagnose ATTR amyloidosis at an early stage using a simple approach. Considering the epidemiology of carpal tunnel syndrome and systemic wild-type ATTR amyloidosis, amyloidosis can be ruled out during carpal tunnel release surgery at least for men.</p>

Journal

  • Spinal Surgery

    Spinal Surgery 34 (2), 151-155, 2020

    The Japanese Society of Spinal Surgery

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