Trichothecene biosynthesis in different fungal genera: resistance mechanisms, pathway enzymes, and their product applications.

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  • Takahashi-Ando Naoko
    Graduate School of Science and Engineering, Toyo University
  • Matsui Kosuke
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
  • Suzuki Tamotsu
    Graduate School of Science and Engineering, Toyo University
  • Sadamatsu Kazuki
    Graduate School of Science and Engineering, Toyo University
  • Azuhata Hayato
    Graduate School of Science and Engineering, Toyo University
  • Okada Ayaki
    Graduate School of Science and Engineering, Toyo University
  • Matsuo Genki
    Graduate School of Science and Engineering, Toyo University
  • Takeda Hirone
    Graduate School of Science and Engineering, Toyo University
  • Koizumi Yoshiaki
    Graduate School of Science and Engineering, Toyo University
  • Kimura Makoto
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University

Bibliographic Information

Other Title
  • トリコテセン耐性に関わる側鎖修飾と異種異属のトリコテセン生産菌を利用したトリコテセンライブラリーの構築
  • トリコテセン タイセイ ニ カカワル ソクサ シュウショク ト イシュイゾク ノ トリコテセン セイサンキン オ リヨウ シタ トリコテセンライブラリー ノ コウチク

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Description

<p>  Food and environmental exposure to trichothecenes, a group of mycotoxins produced by filamentous fungi such as Fusarium, Trichothecium, Trichoderma, and Myrothecium, threatens the health of humans and livestock. The toxins are conventionally classified into types A through D based on their characteristic chemical structures (e.g., the presence of C-8 ketone, 7,8-epoxide, or macrocyclic ring between C-4 and C-15). However, from the viewpoint of biosynthesis, it is more reasonable to classify them into two groups, C-3 unoxygenated d-type trichothecenes and C-3 oxygenated t-type trichothecenes, which are produced by the cyclization of isotrichodiol and isotrichotriol, respectively. Using molecular genetic approaches, we characterized the biosynthetic enzymes of several trichothecene-producing fungi and identified many natural and unnatural trichothecenes. Based on our achievements, an MS/MS library comprising various trichothecene intermediates is being constructed. We believe that in the near future, our MS/MS library will be useful for detecting the emergence of novel trichothecenes.</p>

Journal

  • JSM Mycotoxins

    JSM Mycotoxins 70 (2), 67-74, 2020-07-31

    Japanese Society of Mycotoxicology

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