A Case of Adult T-cell Leukemia with a Laryngeal Tumor

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  • Wakisaka Risa
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Nomura Kenichiro
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Kumai Takumi
    Department of Innovative Head & Neck Cancer Research and Treatment (IHNCRT), Asahikawa Medical University
  • Kishibe Kan
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Takahara Miki
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Katada Akihiro
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University
  • Hayashi Tatsuya
    Department of Innovative Head & Neck Cancer Research and Treatment (IHNCRT), Asahikawa Medical University
  • Harabuchi Yasuaki
    Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University

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Other Title
  • 喉頭病変が初発病変であった成人T細胞白血病の一例

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<p>We herein report the case of a patient with adult T-cell leukemia of the larynx.Adult T cell Leukemia was first described by Takatsuki in 1975. ATL is associated with human T cell lymphotropic virus typeⅠ(HTLV-1). Patients with this condition usually show lymphadenopathy and skin rash. The association of local laryngeal mass lesions is rare.</p><p>The patient, a 67-year-old woman, complained of throat pain that persisted for two weeks. She had a tumor of the epiglottis as well as cervical lymphadenopathy, and ulceration of a finger. To obtain a definite diagnosis, we obtained a biopsy specimen from the laryngeal tumor; however, the lesion was necrotic. Thus, we then obtained a biopsy specimen of the right cervical lymph node. The pathological findings suggested malignant lymphoma originating from the T cells. HTLV-1 was found in her serum, and a provirus was identified in ATL cells. The patient was treated with chemotherapy and the epiglottal mass gradually disappeared.</p><p>Otolaryngologists should consider ATL in the differential diagnosis of laryngeal carcinoma.</p>

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