Development of an intratympanic dosing method for evaluation of ototoxicity in guinea pigs
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- YOSHIKAWA Tetsuya
- Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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- MISHIMA Minoru
- Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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- NISHI Hideki
- Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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- TAURA Mitsumi
- Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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- UCHIMURA Mie
- Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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- NAGAOKA Takaharu
- Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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- TSUSAKI Hideshi
- Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.
Bibliographic Information
- Other Title
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- 聴器毒性評価におけるモルモット鼓室内投与法の検討
Abstract
<p>We developed a new method of intratympanic (ITy) dosing involving puncture of the eardrum in male guinea pigs and evaluated the effects on the auditory system by auditory brainstem response (ABR), histopathology, and scanning electron microscopy. In the 10-day repeated dose (100 μL/ear), saline and 4% gentamicin showed elevated ABR thresholds (ABRt); furthermore, gentamicin showed a loss of inner and outer hair cells in the ductus cochlearis. In the weekly dose (4 times) of saline, no ABRt changes were noted. From these results, ITy dosing is useful for ototoxicity evaluation in guinea pigs.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-152-, 2020
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390285697591511296
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- NII Article ID
- 130007898275
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed