The role of TNF-α in methylmercury-induced neurotoxicity

DOI
  • KATAMI Fumika
    Department of Environmental Health, Faculty of Pharmaceutical Science, Tokyo University of Science
  • YOSHIDA Eiko
    Department of Environmental Health, Faculty of Pharmaceutical Science, Tokyo University of Science
  • SHINODA Yo
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy & Life Science
  • FUJIWARA Yasuyuki
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy & Life Science
  • KAJI Toshiyuki
    Department of Environmental Health, Faculty of Pharmaceutical Science, Tokyo University of Science

Bibliographic Information

Other Title
  • メチル水銀の神経毒性におけるTNF-αの役割

Description

<p>Our previous study suggested that TNF-α may be involved in the selective damage of sensory neurons by methylmercury (MeHg). To examine this possibility, toxicity of MeHg was compared between wild type (WT) mice and TNF-α deficient (KO) mice. Survival, weight loss, mercury accumulation, and hind limb extension symptoms were evaluated after oral administration of MeHg. The results indicate that TNF-α is involved at least in the hind limb extension symptoms caused by MeHg.</p>

Journal

Details 詳細情報について

  • CRID
    1390285697591546240
  • NII Article ID
    130007898309
  • DOI
    10.14869/toxpt.47.1.0_p-14s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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