Tetrabromobisphenol A(TBBPA), a brominated flame retardant, causes depression-like behavior in mice

FUKUZAWA Ryohei A., NAKAJIMA Akira A.

doi:10.14869/toxpt.47.1.0_p-20s

[Introduction]Tetrabromobisphenol A(TBBPA) is the most widely used type of brominated flame retardant, which is employed as additives in the manufacturing of office and home electronic equipment. Information about neurotoxicity is limited, despite TBBPA is suspected to be stable in the environment with possible widespread human exposures. In this study, we investigated the effects of TBBPA on emotional behavior in mice.[Method]Male ddY mice（8 weeks old）were orally administered TBBPA 500 mg/kg bw daily for two weeks, and the effects of TBBPA on anxiety- and depression-like behavior were examined in behavioral tests. The behavioral tests consist of the open field test, elevated plus-maze test, and forced swim test.[Results and Discussion]In the open field test, there was no difference in the number of entries into the center area, the amount of time spent in center area, and total distance between vehicle- and TBBPA-treated groups. In the elevated plus-maze test, administration of TBBPA did not alter the number of open arm entry and time spent in open arm. These results suggest that TBBPA did not affect anxiety-like behavior in mice. In the forced swim test, TBBPA administration resulted in an increase in the immobility time.[Conclusions]These results suggest that TBBPA, a brominated flame retardant, did not affect anxiety-like behavior but caused depression-like behavior in mice.

Tetrabromobisphenol A(TBBPA), a brominated flame retardant, causes depression-like behavior in mice

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