Functional roles of TRAF2 in cisplatin-induced apoptosis
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- SHIMADA Tatsuya
- Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
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- TSUCHIDA Mei
- Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
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- YOKOSAWA Takumi
- Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
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- HIRATA Yusuke
- Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
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- NOGUCHI Takuya
- Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
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- MATSUZAWA Atsushi
- Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
Bibliographic Information
- Other Title
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- シスプラチン誘導性アポトーシスにおけるTRAF2の機能的役割
Description
<p>Tumor necrosis factor receptor-associated factor 2 (TRAF2) both positively and negatively regulates stress-induced cell death. However, roles of TRAF2 in DNA damage-induced cell death remain unknown. In this study, we assessed the roles of TRAF2 in DNA damage-induced cell death induced by cisplatin, a representative DNA-damaging agent. TRAF2-deficient cells exhibit significant resistance to cisplatin-induced apoptosis, accompanied by the reduction of p53 protein level. Thus, our results suggest that TRAF2 promotes cisplatin-induced apoptosis through p53-dependent mechanisms.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-73S-, 2020
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390285697591711232
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- NII Article ID
- 130007898544
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed