Functional roles of TRAF2 in cisplatin-induced apoptosis

DOI
  • SHIMADA Tatsuya
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • TSUCHIDA Mei
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • YOKOSAWA Takumi
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • HIRATA Yusuke
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • NOGUCHI Takuya
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • MATSUZAWA Atsushi
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.

Bibliographic Information

Other Title
  • シスプラチン誘導性アポトーシスにおけるTRAF2の機能的役割

Abstract

<p>Tumor necrosis factor receptor-associated factor 2 (TRAF2) both positively and negatively regulates stress-induced cell death. However, roles of TRAF2 in DNA damage-induced cell death remain unknown. In this study, we assessed the roles of TRAF2 in DNA damage-induced cell death induced by cisplatin, a representative DNA-damaging agent. TRAF2-deficient cells exhibit significant resistance to cisplatin-induced apoptosis, accompanied by the reduction of p53 protein level. Thus, our results suggest that TRAF2 promotes cisplatin-induced apoptosis through p53-dependent mechanisms.</p>

Journal

Details 詳細情報について

  • CRID
    1390285697591711232
  • NII Article ID
    130007898544
  • DOI
    10.14869/toxpt.47.1.0_p-73s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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