Investigation of the Responsiveness to Liver Injury in hL-FABP Tg mice

DOI
  • UNO Kinuko
    Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
  • MIYAJIMA Katsuhiro
    Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • RYU Kanjiro
    Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
  • OHATA Keiichi
    L-FABP Business Department, CMIC Holdings CO., Ltd.
  • KEMURIYAMA Noriko
    Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • NAKAE Dai
    Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture

Bibliographic Information

Other Title
  • hL-FABP Tgマウスの肝障害に対する反応性の検討

Description

<p>Liver-derived L-FABP is reported to be a potential of disease biomarker for NAFLD/ NASH and viral hepatitis in human patients. CCl4 was administrated subcutaneously once to hL-FABP Tg mice at the dose levels of 2.5, 5 and 10 mL/kg. After 24, 48 and 72 hours of administration, the hepatotoxicity and levels of serum hL-FABP were evaluated. hL-FABP was reached the maximum levels at 24 hours after dosing and then decreased over time with dose-dependently, however, there was no difference in hepatological features at all levels. And the protein expression of hL-FABP in the liver was enhanced over time. The mechanism of these changes will be analyzed.</p>

Journal

Details 詳細情報について

  • CRID
    1390285697591779712
  • NII Article ID
    130007898539
  • DOI
    10.14869/toxpt.47.1.0_p-78s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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