Design and Creation of Functional Membrane-Interacting Peptides
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- 二木 史朗
- Institute for Chemical Research, Kyoto University
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<p>Peptides provide a unique platform for creation of biofunctional molecules. Peptide design can be motivated by natural protein structures or attained de novo. For designed peptides to exert expected functions, a specific structure is needed whereby membranes can be employed to obtain stabilized helical structures. In biological systems, membranes are not limited to simple barriers between the extracellular and intracellular spaces or barriers that delineate intracellular compartments; they also stabilize the structures of peptides and proteins. Here, we review our approaches to the creation of membrane-interacting amphiphilic peptides as artificial ligand-gated ion channels, enhancers of cellular uptake of bioactive materials, and modulators of membrane lipid packing.</p>
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 78 (11), 1058-1065, 2020-11-01
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390286426511546752
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- NII論文ID
- 130007937276
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 030772378
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- KAKEN
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- 使用不可