第２章　日本の創薬技術と医薬品開発の変遷（1980～2010）

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タイトル別名
  • Chapter 2. Transitions in drug-discovery technology and drug-development in Japan (1980-2010)
  • 薬史学特集号 日本の創薬技術と医薬品開発の変遷(1980~2010)
  • クスリ シガク トクシュウゴウ ニホン ノ ソウヤク ギジュツ ト イヤクヒン カイハツ ノ ヘンセン(1980~2010)

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抄録

In 1970s, the material patent system was introduced in Japan. Since then, many Japanese pharmaceutical companies have endeavored to create original in-house products. From 1980s, many of the innovative products were small molecular drugs and were developed using powerful medicinal-chemical technologies. Among them were antibiotics and effective remedies for the digestive organs and circulatory organs. During this period, Japanese companies were able to launch some blockbuster drugs. At the same time, the pharmaceutical market, which had grown rapidly for two decades, was beginning to level off. From the late 1990s, drug development was slowing down due to the lack of expertise in biotechnology such as genetic engineering. In response to the circumstances, the research and development on biotechnology-based drugs such as antibody drugs have become more dynamic and popular at companies than small molecule drugs. In this paper, the writers reviewed in detail the transitions in drug discovery and development between 1980 and 2010. PMID: 25272636 [Indexed for MEDLINE]

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