Impact of Metabolic Syndrome on the Mortality Rate among Participants in a Specific Health Check and Guidance Program in Japan
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- Iseki Kunitoshi
- Clinical Research Support Center, Nakamura Clinic, Japan
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- Konta Tsuneo
- Department of Public Health and Hygiene, Yamagata University School of Medicine, Japan
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- Asahi Koichi
- Division of Nephrology and Hypertension, Iwate Medical University, Japan
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- Yamagata Kunihiro
- Division of Nephrology, Faculty of Medicine, Tsukuba University, Japan
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- Fujimoto Shouichi
- Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Japan
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- Tsuruya Kazuhiko
- Division of Nephrology, Nara Medical University, Japan
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- Narita Ichiei
- Division of Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medicine and Dental Sciences, Japan
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- Kasahara Masato
- Institute for Clinical and Translational Science, Nara Medical University Hospital, Japan
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- Shibagaki Yugo
- Division of Nephrology and Hypertension, St. Marianna University School of Medicine, Japan
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- Moriyama Toshiki
- Health and Counseling Center, Osaka University, Japan
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- Kondo Masahide
- Graduate School of Comprehensive Human Science, University of Tsukuba, Japan
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- Iseki Chiho
- Okinawa Heart and Renal Association, Japan
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- Watanabe Tsuyoshi
- Fukushima Rosai Hospital, Japan
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説明
<p>Objective In Japan, the Specific Health Check and Guidance (Tokutei-Kenshin) program was started in 2008 to decrease the social burden related to metabolic syndrome (MetS). However, so far this program has not been found to have any impact on the mortality rate. </p><p>Methods The subjects consisted of individuals who participated in the Tokutei-Kenshin in seven districts between 2008 and 2015. Using a National database of death certificates, we identified those who might have died and then further confirmed such deaths with the collaboration of the regional National Health Insurance agency and public health nurses. The diagnosis of MetS was made according to the Japanese criteria. The causes of death were classified by ICD-10. Mortality risk was evaluated after adjusting for age, sex, smoking, alcohol intake and past medical history such as stroke, heart disease and kidney disease. </p><p>Results Among the total of 664,926 subjects, we identified 8,051 fatal cases by the end of 2015. The crude death rate was 1.6% for those with MetS, 1.3% for those with preliminary metabolic syndrome, and 1.1% those without MetS. In MetS, the adjusted hazard ratio (95% confidence interval) was 1.08 (1.02-1.15) for all-cause and 1.39 (1.22-1.58) for cardiovascular disease mortality when the reference was for those without MetS. </p><p>Conclusion The death rate was found to be significantly higher among the participants with MetS. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 59 (21), 2671-2678, 2020-11-01
一般社団法人 日本内科学会