ミエロペルオキシダーゼ染色が弱陽性を呈し形態学的診断が困難であった急性前骨髄球性白血病microgranular type

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タイトル別名
  • Microgranular-type acute promyelocytic leukemia with weak myeloperoxidase staining: difficulty of morphological diagnosis
  • ミエロペルオキシダーゼ センショク ガ ジャク ヨウセイ オ テイシ ケイタイガクテキ シンダン ガ コンナン デ アッタ キュウセイ ゼン コツズイキュウセイ ハッケツビョウ microgranular type

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説明

<p>The 2017 World Health Organization (WHO) classification states that acute promyelocytic leukemia (APL) always presents with strong myeloperoxidase staining. However, we herein report of a 40-year-old woman with the microgranular variant of acute promyelocytic leukemia presenting with weak myeloperoxidase (MPO) staining. The leukemic cells were morphologically similar to monocytic cells, showing distorted-shaped nuclei and weak MPO staining. However, flow cytometry revealed positivity of CD2, CD34, and human leucocyte antigen-DR (HLA-DR) and pointed toward a diagnosis of APL. PML-RARA mRNA detection finally led the patient to a definitive diagnosis. The patient achieved complete remission by induction chemotherapy including tretinoin, cytarabine and idarubicin, and no differentiation syndrome was observed.</p>

収録刊行物

  • 臨床血液

    臨床血液 61 (10), 1511-1513, 2020

    一般社団法人 日本血液学会

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