A Case of Urticarial-type Drug Eruption Caused by Moxifloxacin

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  • NOMURA Yuki
    Department of Dermatology, Kansai Medical University
  • UETSU Naoko
    Department of Dermatology, Kansai Medical University Uetsu Clinic Department of Allergy Center, Kansai Medical University Hospital
  • KISHIMOTO Izumi
    Department of Dermatology, Kansai Medical University Department of Allergy Center, Kansai Medical University Hospital
  • KAMBE Naotomo
    Department of Dermatology, Kansai Medical University Department of Allergy Center, Kansai Medical University Hospital
  • OKAMOTO Hiroyuki
    Department of Dermatology, Kansai Medical University

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Other Title
  • モキシフロキサシン塩酸塩による蕁麻疹型薬疹の１例
  • 症例 モキシフロキサシン塩酸塩による蕁麻疹型薬疹の1例
  • ショウレイ モキシフロキサシン エンサンエン ニ ヨル ジンマシンガタヤクシン ノ 1レイ

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Abstract

<p>A 62-year-old woman took moxifloxacin hydrochloride, carbocysteine, and toloxipide for 4 days and β-methadone and d-chlorpheniramine Maleate for 2 days for sinusitis. One month later, she developed wheals and erythema on her entire body (except the face) about 2 hours after taking moxifloxacin hydrochloride, carbocysteine, and mequitazine once. The rash disappeared about 3 hours after the administration of olopatadine hydrochloride. Suspecting drug eruption, we performed a prick test and a scratch test for each drug (moxifloxacin hydrochloride, carbocysteine, toloxipide, and mequitazine) . A positive reaction was seen only at the site where the moxifloxacin hydrochloride scratch test was performed. It is known that moxifloxacin hydrochloride can cause an urticarial-type drug eruption on the first dose, but in this case, sensitization was achieved on the first dose, and it was suggested that an immediate response was obtained on the second dose, one month later.</p><p>(日本皮膚免疫アレルギー学会雑誌, 3 (3) : 425-429, 2020)</p>

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