質量分析イメージングにおける組織上誘導体化試薬FMP-10の使用法

新間 秀一

doi:10.5702/massspec.20-112

書誌事項

タイトル別名

How to Use the Derivatization Reagent of FMP-10 for Mass Spectrometry Imaging
シツリョウブンセキイメージングニオケルソシキジョウユウドウタイカシヤク FMP-10 ノシヨウホウ

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説明

<p>In mass spectrometry imaging (MSI), tissue derivatization is now an essential technique for visualizing previously unseen molecules due to increased sensitivity. Scientists find various tissue derivatization methods for MSI reported since 2011. The most recent derivatization reagent is 4-(anthracen-9-yl)-2-fluoro-1-methylpyridin-1-ium iodide (FMP-10). The reagent derivatizes a phenolic hydroxyl group and a primary amine group. Because of the characteristics, the derivatization of FMP-10 visualizes various neurotransmitters. However, due to the reagent's high cost, the original paper's method is difficult to use practically. In this note, I will introduce an experimental technique to improve sensitivity with small amounts of FMP-10.</p>

収録刊行物

質量分析

質量分析 68 (6), 106-109, 2020-12-01

一般社団法人日本質量分析学会

詳細情報詳細情報について

CRID: 1390286981359707264

NII論文ID: 130007955840

NII書誌ID: AN0010555X

DOI: 10.5702/massspec.20-112

ISSN: 18804225; 18843271; 13408097

NDL書誌ID: 030804746

Web Site: http://id.ndl.go.jp/bib/030804746; https://ndlsearch.ndl.go.jp/books/R000000004-I030804746; https://www.jstage.jst.go.jp/article/massspec/68/6/68_20-112/_pdf

本文言語コード: ja

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