A case of anti-SRY-Related HMG-Box Gene 1 (SOX1) antibody-positive chorea

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  • 抗SRY-Related HMG-Box Gene 1(SOX1)抗体陽性の舞踏運動の1例

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Abstract

<p>A 77-year-old man with a history of lung cancer at the age of 71 developed involuntary right leg movement for a month. Neurological examination revealed a right-sided hemi-chorea. Autoimmune disease was suspected owing to the presence of oligoclonal bands and the elevated IgG-index in the cerebrospinal fluid. We detected anti-SRY-Related HMG-Box Gene 1 (SOX1) antibodies, known to be serological markers of Lambert-Eaton syndrome with small cell lung cancer, but not tumors. The results of tests for antiphospholipid, anti-LGI1, and anti-CASPR2 antibodies associated with non-paraneoplastic autoimmune chorea were all negative. This is the first suggestive case of autoimmune chorea in which anti-SOX1 antibodies were detected.</p>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 60 (12), 852-856, 2020

    Societas Neurologica Japonica

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