A case of anti-SRY-Related HMG-Box Gene 1 (SOX1) antibody-positive chorea
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- M.D. Yamagishi Takuma
- Department of Neurology, Akita Red Cross Hospital
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- M.D. Inoue Kana
- Department of Neurology, Akita Red Cross Hospital
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- M.D. Ouchi Haruka
- Department of Neurology, Akita Red Cross Hospital
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- M.D., Ph.D. Shibano Ken
- Department of Neurology, Akita Red Cross Hospital
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- M.D., Ph.D. Hara Kenju
- Department of Neurology, Akita Red Cross Hospital
Bibliographic Information
- Other Title
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- 抗SRY-Related HMG-Box Gene 1（SOX1）抗体陽性の舞踏運動の1例
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Abstract
<p>A 77-year-old man with a history of lung cancer at the age of 71 developed involuntary right leg movement for a month. Neurological examination revealed a right-sided hemi-chorea. Autoimmune disease was suspected owing to the presence of oligoclonal bands and the elevated IgG-index in the cerebrospinal fluid. We detected anti-SRY-Related HMG-Box Gene 1 (SOX1) antibodies, known to be serological markers of Lambert-Eaton syndrome with small cell lung cancer, but not tumors. The results of tests for antiphospholipid, anti-LGI1, and anti-CASPR2 antibodies associated with non-paraneoplastic autoimmune chorea were all negative. This is the first suggestive case of autoimmune chorea in which anti-SOX1 antibodies were detected.</p>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 60 (12), 852-856, 2020
Societas Neurologica Japonica