Heat Dose Based Large Tumor Treatment with Multiple Site Injections of Heat-generating Nanoparticles Dispersible within Tumor Tissue

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  • MORINO TOMIO
    Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences
  • ITO AKIRA
    Department of Chemical Systems Engineering, School of Engineering, Nagoya University
  • ETANI TOSHIKI
    Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences
  • NAIKI TAKU
    Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences
  • KAWAI NORIYASU
    Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences
  • YASUI TAKAHIRO
    Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences

Bibliographic Information

Other Title
  • 腫瘍内分散性と発熱性を有するマグネタイト正電荷脂質複合粒子の腫瘍内マルチサイト投与法を用いた大型腫瘍の治療条件とその完全退縮効果
  • シュヨウ ナイ ブンサンセイ ト ハツネツセイ オ ユウスル マグネタイト セイ デンカ シシツ フクゴウ リュウシ ノ シュヨウ ナイ マルチサイト トウヨホウ オ モチイタ オオガタ シュヨウ ノ チリョウ ジョウケン ト ソノ カンゼンタイシュクコウカ

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Abstract

<p>Solid cancer therapy based on necrosis induction with heat-generating nanoparticles has been developed in Japan. Heat was induced from intratumorally injected magnetite cationic lipid composite particles (MCL particles) by alternating magnetic field irradiations to kill cancer cells nearby located. In our previous report we have showed importance of heat dose index in vivo (J/cm3 tumor volume) for tumor regression when 45 mg MCL particles were injected at a single site of 1.36 cm3 tumor. Purpose of this study is to show rationale and utility of multiple site injections of MCL particles for treatment of large tumors more than 1.36 cm3.</p><p>Rat mammary tumors were induced by 7,12-dimethylbenz［a］anthracene (DMBA) and tumors in range of 2.19 ～ 3.81 cm3 were applied to treatment experiment. Treatment condition was designed to reproduce the heat generation condition of the 1.36 cm3 tumor treatment at every multiple injection site in rat mammary tumors. Tumor volume divided by number of injection sites (cm3/site) was set to close to 1.36 cm3/site and 45 mg MCL particles were administered at multiple sites to keep even spaces among injection sites. Three irradiation conditions were set to give close heat dose in vivo (J/cm3) of the 1.36 cm3 tumor treatment. Treatment under designed conditions resulted in complete regression of rat tumors at 21 days after the treatment, showing theoretical validity of design procedures for the multiple site injections. Novel concept of necrosed tumor volume from an injection site (cm3/site) and its actual value under a standard injection condition of 45 mg-MCL/site were described and its use in clinic was discussed.</p>

Journal

  • Thermal Medicine

    Thermal Medicine 36 (4), 101-108, 2020-12-25

    Japanese Society for Thermal Medicine

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