Amyloid β Assemblies Induced by Highly–enriched Ganglioside Nanoclusters

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  • Matsubara Teruhiko
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • Sato Toshinori
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

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Other Title
  • 高密度ガングリオシドクラスターが誘起する アミロイドβの集合体形成
  • コウミツド ガングリオシドクラスター ガ ユウキ スル アミロイドv ノ シュウゴウタイ ケイセイ

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Abstract

The assembly of amyloid β protein (Aβ) on membrane microdomains in presynaptic neuronal membranes is involved in the onset of Alzheimer’s disease. The Aβ– sensitive ganglioside nanocluster (ASIGN) was identified by the surface topography of the lipid bilayers composed of brain–extracted lipids. Our results indicate that the ganglioside clustering is responsible for the Aβ– assemblies on the neuronal membranes.

Journal

  • MEMBRANE

    MEMBRANE 46 (1), 7-11, 2021

    THE MEMBRANE SOCIETY OF JAPAN

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