Mind-Body Interaction in Central Sensitization Disorders

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  • Fukudo Shin
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine

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  • 中枢神経感作病態における心身相関
  • チュウスウ シンケイ カンサ ビョウタイ ニ オケル シンシン ソウカン

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<p>Many patients with chronic pain visit Department of Pychosomatic Medicine or allied organization in the university hospitals, general hospitals, or clinics. Patients with chronic somatic pain are classified into chronic pain syndrome, migraine, tension-type headache, glossodynia, temporomandibular joint disorder, cervicobrachial syndrome, low back pain, chronic pelvic pain, and fibromyalgia. Patients with chronic visceral pain are identified as irritable bowel syndrome, centrally-mediated abdominal pain syndrome, narcotic bowel syndrome, epigastric pain syndrome, functional chest pain, functional gallbladder disorder, functional biliary sphincter of Oddi disorder, functional pancreatic sphincter of Oddi disorder, levator ani syndrome, unspecified functional anorectal pain, and proctalgia fugax. Among them, visceral pain can be replicated with clinical examination simultaneously with measuring pain threshold. Research on visceral pain has been developed by the effort searching pathophysiology and pathogenesis of irritable bowel syndrome. Research on irritable bowel syndrome is a prototype of investigation not only on functional gastrointestinal disorders but also on chronic visceral pain. Irritable bowel syndrome overlaps with many chronic pain disorders as well as anxiety disorders, depressive disorders, and somatic symptom and related disorders. Much effort has been paid attention to seek intracerebral mechanism of sensitization of neurons which code pain. Further research is warranted to alleviate pain in patients with chronic pain.</p>

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