Bio-inert Properties of TEG Modified Dendrimer Interface

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Abstract

<p>The bioinert interfaces that prevent adhesion of proteins and cells are important for biomaterial applications. In order to design a bioinert interface, the immobilization of an appropriate functional group and the control of molecular density is required. Dendrimer was modified with triethylene glycol (TEG) to display a dense brush structure. TEG with different density and terminal groups were immobilized with a dendrimer template and thiol terminated molecules. The inhibitory effect on protein and bacteria binding was investigated. The physical property of the interface was measured by QCM-admittance to clarify the factor of the bioinert property.</p>

Journal

  • Analytical Sciences

    Analytical Sciences 37 (3), 519-523, 2021-03-10

    The Japan Society for Analytical Chemistry

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