- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
CLINICAL SIGNIFICANCE OF IRREGULAR ANTIBODY BASED ON IgG SUBCLASS ANALYSIS
-
- Hasunuma Hidekazu
- Division of Blood Transfusion, Toho University Sakura Medical Center
-
- Ishida Tomoko
- Division of Blood Transfusion, Toho University Sakura Medical Center
-
- Machida Tamotsu
- Division of Blood Transfusion, Toho University Sakura Medical Center
-
- Iwashita Yoichi
- Division of Blood Transfusion, Toho University Sakura Medical Center
-
- Shimizu Naomi
- Division of Blood Transfusion, Toho University Sakura Medical Center Department of Hematology, Toho University Sakura Medical Center
Bibliographic Information
- Other Title
-
- IgGサブクラス解析から検討した不規則抗体の臨床的意義
Search this article
Description
<p>Background: Detection of IgG antibodies using an indirect anti-globulin analysis is generally useful as a clinical laboratory examination. IgG has four subclasses, of which IgG1 and IgG3 have high complement binding activities which are reported to be frequently involved in hemolytic reactions. The purpose of this study was to evaluate the clinical significance of IgG subclasses regarding the respective alloantibodies or autoantibodies.</p><p>Methods: We measured fluorescence intensities by flow cytometry to investigate titers of erythrocyte-bound IgG subclasses in patients (n = 185) with anti-D, anti-E, anti-c, anti-e, anti-Fyb, anti-Dia, anti-Jka, anti-Jkb and warm autoantibodies. Further, we performed monocyte monolayer assay (MMA) in about 30 of these cases to confirm clinical significance.</p><p>Results: The IgG subclasses IgG1 and IgG3 were common as a single antibody, while IgG1+IgG3 was common as multiple antibodies. In patients with anti-E antibody, single antibody with IgG1 or multiple antibodies with IgG1+IgG3, respectively, were common. High levels of cell-bound IgG3 showed a high phagocytic ratio in MMA.</p><p>Conclusions: IgG3 and IgG1+IgG3 alloantibodies in patients with anti-E antibody warrant further investigation.</p>
Journal
-
- Japanese Journal of Transfusion and Cell Therapy
-
Japanese Journal of Transfusion and Cell Therapy 67 (1), 1-8, 2021-02-25
The Japan Society of Transfusion Medicine and Cell Therapy
- Tweet
Details 詳細情報について
-
- CRID
- 1390287373996631680
-
- NII Article ID
- 130007999710
-
- ISSN
- 18830625
- 18813011
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
-
- Abstract License Flag
- Disallowed
