Social cognitive improvement via activation of the hippocampal α7 nicotinic acetylcholine receptor in stressed mice
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- Hosoi Kana
- Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm.
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- Uchida Mizuki
- Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm.
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- Ota Erika
- Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm.
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- Yoshimi Akira
- Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm.
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- Ozaki Norio
- Dept. Psychiatry, Nagoya Univ. Grad. Sch. Med.
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- Noda Yukihiro
- Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm.
Bibliographic Information
- Other Title
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- ストレス負荷マウスにおける海馬α7ニコチン性アセチルコリン受容体の活性化を介した社会的認知の改善
Abstract
<p>[Purpose] Social cognition is a key factor of rehabilitation in stress-related disorders. The α7 nicotinic acetylcholine receptor (nAChR) is a promising target for the treatment of cognitive deficits associated with psychiatric and neurological disorders. In this study, we investigated the involvement of α7 nAChR in the social cognition of stressed mice.</p><p>[Methods] The male C57BL/6J mice at age of 7 weeks were exposed to swimming stress for 15 min. Administration of PHA568487 (PHA: 0.3 mg/kg i.p.), an α7 nAChR agonist was commenced once a day for 7 consecutive days from the next day of stress exposure. </p><p> [Results] The stressed mice showed the impairment of social cognition in the three-chamber social interaction test, the decreased expression of α7 nAChR subunit protein and the ratio of Akt, CaMKⅡ, and ERK phosphorylation in the hippocampus (HIP). These abnormalities were attenuated by repeated treatment with PHA. </p><p> [Conclusions] Our findings indicated that stress exposure impaired the social cognition via decreasing α7 nAChR-related intracellular signaling in the HIP. Since repeated treatment with PHA attenuated these behavioral and neurochemical changes, α7 nAChR may be one of the new therapeutic targets for the impairment of social cognition in stress-related disorders.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (0), 2-P1-36-, 2021
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390287441187129856
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- NII Article ID
- 130008001403
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed