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- Kato Masaki
- Dept. Pharmacol., Osaka Univ. Pharm. Sci.
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- Kunisawa Naofumi
- Dept. Pharmacol., Osaka Univ. Pharm. Sci.
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- Shimizu Saki
- Dept. Pharmacol., Osaka Univ. Pharm. Sci.
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- Takashima Chihiro
- Dept. Pharmacol., Osaka Univ. Pharm. Sci.
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- Tsujimura Kana
- Dept. Pharmacol., Osaka Univ. Pharm. Sci.
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- Horikawa Kazuya
- Dept. Pharmacol., Osaka Univ. Pharm. Sci.
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- Ohno Yukihiro
- Dept. Pharmacol., Osaka Univ. Pharm. Sci.
Bibliographic Information
- Other Title
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- ドパミン神経系によるニコチン誘発振戦の発現調節機構
Abstract
<p>Nicotine excites the inferior olive (IO) neurons and induces kinetic tremor via activating α7 nACh receptors. Meanwhile, nicotine is also known to enhance dopamine release by activating presynaptic nACh receptors, but the role of dopaminergic system in regulating nicotine-induced tremor remains unknown. Here, we investigated the effect of various dopamine receptor antagonists on nicotine-induced tremor in mice and rats. Animals were pretreated with dopamine antagonists 15 min before nicotine (1 mg/kg) injection. Nicotine tremor was significantly facilitated by the selective D1/5 antagonist SCH-23390 while it was significantly inhibited by the D3 selective antagonist U-99194. Neither D2 (L-741,626) nor D4 antagonist (L-745,870) affected nicotine tremor. In addition, microinjection of SCH-23390 into the IO tended to enhance nicotine tremor, but its injection into the striatum showed no effect. Microinjection of U-99194 into the IO or the striatum did not change nicotine tremor, however, its injection into the cerebellum significantly attenuated nicotine tremor. These results suggest that the dopaminergic system regulates nicotine-induced tremor biphasically, D3 receptors in the cerebellum being facilitatory and D1/5 receptors in the IO inhibitory.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (0), 1-P1-09-, 2021
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390287441187722752
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- NII Article ID
- 130008001189
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed