Antidiabetic Drug-Related Severe Hypoglycemia -An Analysis of Patients Who Visited the Emergency Outpatient Unit of Our Hospital Over 10 Years-

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  • Matsuoka Yuko
    Clinical Center for Diabetes, Fuchu Hospital, Seichokai Social Medical Corporation
  • Kadoya Yoshiki
    Clinical Center for Diabetes, Fuchu Hospital, Seichokai Social Medical Corporation
  • Yamada Shoichi
    Clinical Center for Diabetes, Fuchu Hospital, Seichokai Social Medical Corporation
  • Nishiyama Akihide
    Emergency Center, Fuchu Hospital, Seichokai Social Medical Corporation
  • Sanke Tokio
    Institute for Diabetes, Fuchu Hospital, Seichokai Social Medical Corporation

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  • 糖尿病治療薬による重症低血糖―10年間に当院救急受診した患者の解析より―

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Abstract

<p>We investigated the emergency outpatients with diabetes due to drug-related severe hypoglycemia (requiring external assistance for recovery) who visited our hospital over a 10-year period (between April 2009 and March 2019) and found 329 cases (0.66 % of emergency outpatients). Elderly and lean patients accounted for the largest group. Patients with type 1 diabetes accounted for at least 11.2 % of patients. The mode of treatment was insulin in 42.2 %, combined usage of insulin and an oral hypoglycemic agent (OHA) in 16.4 %, and an OHA in 41.3 %. Most (86 %) patients treated with an OHA were administered sulfonylureas (SU). Among the patients treated with SU, 25.9 % had a reduced renal function, and 29.9 % were co-treated with a dipeptidyl-peptidase-4 inhibitor. Both the annual number of patients and their annual ratio to emergency outpatients peaked in 2009 and then decreased gradually. These decreases were largely due to a decrease in patients treated with SU.</p>

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