Chronic myeloid leukemia with variant e13a3 (b2a3) <i>BCR-ABL1</i> as an ABL1 tyrosine kinase inhibitor-sensitive subtype
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- TOGITANI Kazuto
- Department of Hematology, Kochi Medical School, Kochi University
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- ASAGIRI Tadashi
- Department of Laboratory Medicine, University of Kochi
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- KAMIOKA Mikio
- Department of Laboratory Medicine, Tenri Yorozu Hospital
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- KOJIMA Kensuke
- Department of Hematology, Kochi Medical School, Kochi University
Bibliographic Information
- Other Title
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- 良好なABL1チロシンキナーゼ阻害薬感受性を示したバリアントe13a3(b2a3)<i>BCR-ABL1</i>慢性骨髄性白血病
- 良好なABL1チロシンキナーゼ阻害薬感受性を示したバリアントe13a3(b2a3)BCR-ABL1慢性骨髄性白血病
- リョウコウ ナ ABL1 チロシンキナーゼ ソガイヤク カンジュセイ オ シメシタ バリアント e13a3(b2a3)BCR-ABL1 マンセイ コツズイセイ ハッケツビョウ
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Abstract
<p>We report the case of a 26-year-old male patient with chronic myelogenous leukemia in the chronic phase with the e13a3 (b2a3) variant of BCR-ABL1 fusion. Despite the presence of Philadelphia chromosome and fluorescence in situ hybridization-detectable BCR-ABL1 fusion signals, quantitative measurement of BCR-ABL1 on the ABL1 using a reverse primer in exon 2 of ABL1 failed to detect the fusion transcripts. PCR direct sequencing analysis with a sense primer for exon 13 of BCR and an antisense primer for exon 3 of ABL1 revealed the e13a3 variant of BCR-ABL1 fusion. The variant fusion transcript level was successfully monitored by the TaqMan assay using a forward primer and probe both in exon 13 of BCR and a reverse primer in exon 3 of ABL1. The patient responded extremely well to imatinib treatment, similar to previously reported e13a3 cases. The patient achieved a molecular response (undetectable e13a3 transcripts) after 12 months of treatment.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 62 (3), 180-185, 2021
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390287606256077824
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- NII Article ID
- 130008022236
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 031411158
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- PubMed
- 33828011
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed