Postprandial hormones, insulin and GLP-1, regulate food intake and glucose metabolism via vagal afferent nerves

DOI
  • Iwasaki Yusaku
    Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
  • Yada Toshihiko
    Center for Integrative Physiology, Kansai Electric Power Medical Research Institute Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine

Bibliographic Information

Other Title
  • 食後ホルモンインスリン・GLP-1の求心性迷走神経を介した摂食・糖代謝調節

Abstract

<p>Pancreatic insulin and intestinal glucagon-like peptide-1 (GLP-1) are representative hormones to induce the postprandial actions such as improving postprandial hyperglycemia and inducing satiety. These hormones act on various organs via the classic "humoral pathway" through blood circulation. In addition, we have demonstrated that these hormones, at high concentrations in the vicinity of the secretory tissues, activate the vagal afferents, and thereby control feeding and glucose metabolism. In this review, we describe the direct cooperative action of insulin and GLP-1 on isolated vagal afferent nodose ganglion neurons. We identified rare-sugar D-allulose as a new GLP-1 releaser, and here review the action of D-allulose to regulate feeding and glucose metabolism via GLP-1 release and vagal afferent nerves.</p>

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Details 詳細情報について

  • CRID
    1390287696160769792
  • NII Article ID
    130008025106
  • DOI
    10.32272/ans.58.1_105
  • ISSN
    24347035
    02889250
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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