Effect of 6,9,12,15-Hexadecatetraenoic Acid (C16:4n-1)-Ethyl Ester on Lipid Content and Fatty Acid Composition in the Blood and Organs of Mice

Hosomi Ryota, Tanizaki Toshifumi, Ikawa Shintaro, Tsushima Tadahiro, Misawa Yoshihisa, Baba Naomichi, Yoshida Munehiro, Fukunaga Kenji

doi:10.21748/am21.532

Effect of 6,9,12,15-Hexadecatetraenoic Acid (C16:4n-1)-Ethyl Ester on Lipid Content and Fatty Acid Composition in the Blood and Organs of Mice

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Hosomi Ryota

Department of Life Science and Biotechnology, Kansai University
Tanizaki Toshifumi

Department of Life Science and Biotechnology, Kansai University Bizen Chemical Co., Ltd.
Ikawa Shintaro

Department of Life Science and Biotechnology, Kansai University
Tsushima Tadahiro

Bizen Chemical Co., Ltd.
Misawa Yoshihisa

Bizen Chemical Co., Ltd.
Baba Naomichi

Bizen Chemical Co., Ltd.
Yoshida Munehiro

Department of Life Science and Biotechnology, Kansai University
Fukunaga Kenji

Department of Life Science and Biotechnology, Kansai University

書誌事項

タイトル別名

Effect of 6,9,12,15-Hexadecatetraenoic Acid (C16:4<i>n</i>-1)-Ethyl Ester on Lipid Content and Fatty Acid Composition in the Blood and Organs of Mice
Effect of 6,9,12,15-Hexadecatetraenoic Acid (C16:4n-1)-Ethyl Ester on Lipid Contents and Fatty Acid Compositions in Blood and Organs of Mice

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説明

<p>The effects of 6,9,12,15-hexadecatetraenoic acid (C16:4n-1, HDTA), an n-1 polyunsaturated fatty acid (FA), on plasma and liver lipid content and distribution in blood and tissues were investigated. Mice were fed experimental diets containing 10% HDTA or eicosapentaenoic acid in ethyl ester form based on corn oil for four weeks. Dietary HDTA intake lowered plasma triacylglycerol content without affecting plasma total cholesterol content. HDTA barely accumulated in the epididymal white adipose tissue (eWAT), while C18:4n-1, an HDTA metabolite, was detected in small amounts (< 1% of total FAs) in the plasma, liver, and eWAT.</p>