細胞機能編集に向けた人工オルガネラ創製へのチャレンジ

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  • 岸村 顕広
    九州大学大学院工学研究院応用化学部門 九州大学分子システム科学センター

書誌事項

タイトル別名
  • Challenges to Creation of Artificial Organelle for Effective Editing of Cell Function
  • Symposium Review 細胞機能編集に向けた人工オルガネラ創製へのチャレンジ
  • Symposium Review サイボウ キノウ ヘンシュウ ニ ムケタ ジンコウ オルガネラ ソウセイ エ ノ チャレンジ

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説明

<p>In “cell-function editing”, the combination of biological methods with artificial methods is a promising way to effectively implement functions that live cells do not originally possess. In the present symposium review, two approaches with methodology of building “artificial organelle” were implemented for editing cellular functions. One approach is the “membrane-bound artificial organelle”, which is mainly created from polymeric nanocapsules that function in cells, and the other approach mimics the “membraneless organelle”, which has recently gained immense interest in the field of cell biology. Furthermore, some examples of artificial cells are also described, which were constructed by utilizing artificial organelles. In this context, some recent progress has been observed in the author's research on the development of polyion complex (PIC) materials, in particular, PICsome-based nanoreactors, designer coacervates for protein sequestration, and yolk-shell PIC structures that are reminiscent of artificial cells. These technologies may contribute to effective “cell editing” or “cell renovation”, which enables the edited cells to show higher performance at the target site in the human body, compared to the native cells.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 141 (5), 625-633, 2021-05-01

    公益社団法人 日本薬学会

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