Nucleic Acid Delivery across Biological Barriers

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  • Miyata Kanjiro
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo

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  • 生体内バリアを突破する核酸デリバリー
  • Symposium Review 生体内バリアを突破する核酸デリバリー
  • Symposium Review セイタイナイ バリア オ トッパ スル カクサン デリバリー

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Abstract

<p>One of the current critical issues in nucleic acid delivery is the efficient mRNA delivery into target cells, directed toward clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genome editing. To this end, we have developed a variety of cationic polyaspartamide derivatives with varying side chain structures because they can form nanocomplexes, termed polyplexes, with mRNA through electrostatic interactions. Interestingly, the delivery functions were highly affected by the chemical structures of the polyaspartamide side chains. Therefore, we review our previous research and provide a rationale for designing polypeptides for mRNA delivery.</p>

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  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 141 (5), 635-639, 2021-05-01

    The Pharmaceutical Society of Japan

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