The Korean Pregnancy Outcome Study (KPOS): Study Design and Participants
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- Choi Hansol
- Department of Epidemiology and Health Index, Center for Genome Science, Korea National Institute of Health
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- Kwak Dong Wook
- Department of Obstetrics and Gynecology, Ajou University School of Medicine
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- Kim Min Hyoung
- Department of Obstetrics and Gynecology, Mizmedi Hospital
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- Lee Su Young
- Department of Psychiatry, Myongji Hospital, Hanyang University College of Medicine
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- Chung Jin Hoon
- Department of Obstetrics and Gynecology, Asan Medical Center, Ulsan University Medical School
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- Han You Jung
- Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University
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- Park Hee Jin
- Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University
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- Kim Moon Young
- Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University
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- Cha Dong Hyun
- Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University
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- Koo Seul
- Department of Epidemiology and Health Index, Center for Genome Science, Korea National Institute of Health
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- Lim Joong-Yeon
- Department of Research Planning, Center for Biomedical Science, Korea National Institute of Health
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- Ryu Hyun Mee
- Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University
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- Park Hyun-Young
- Center for Genome Science, Korea National Institute of Health
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<p>Background: The Korean Pregnancy Outcome Study (KPOS) was established to investigate the determinants of adverse pregnancy outcomes among Korean women.</p><p>Methods: We recruited 4,537 pregnant women between 2013 and 2017 from two tertiary centers located in Seoul, Korea, and a total of 4,195 Korean women met inclusion criteria in the baseline analysis. A range of data on socio-demographics, past medical histories, reproductive information, health-related behaviors, psychological health and clinical information were obtained using interviewer-based questionnaires and clinical assessment at 12, 24, and 36 gestational weeks (GW), delivery and 6–8 weeks postpartum. Blood samplings were performed at 12, 24 and 36 GW, and placental tissues were obtained after delivery. The main outcome of this study was pregnancy-related complications including gestational diabetes mellitus (GDM), gestational hypertension, and screening positive for peripartum depression. Depression was assessed using the Korean version of the Edinburgh Postnatal Depression Scale, and a score of ≥10 indicated a positive screen for depression.</p><p>Results: Among 4,195 eligible pregnant women with a median age of 33.0 years, 3,565 (85.0%) pregnancy outcomes were available in this study, including 30 miscarriages, 16 stillbirths, and 3,519 deliveries. Mean gestational age was 38.8 GW, and mean birth weight was 3,236 gram. The prevalence of pregnancy complications of GDM, hypertensive disorders, and screening positive of depression during pregnancy and postpartum was 7.0%, 1.4%, 27.8%, and 16.6%, respectively.</p><p>Conclusions: We designed KPOS to identify the determinants of pregnancy-related outcomes, and it may provide effective strategies for the prevention of pregnancy complications in Korean pregnant women.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 31 (6), 392-400, 2021-06-05
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