An Attempt of the “Sandwich Method” for Extensive Burns:Overlaying Widely Meshed Autografts with aCollagen/Gelatin Scaffold with Sustained Release ofBasic Fibroblast Growth Factor（bFGF）

DOI
  • Yamamoto Kento
    Department of Plastic Surgery, Daiyukai Daiichi Hospital
  • Tanaka Mami
    Department of Plastic and Reconstructive Surgery, Aichi Medical University Hospital
  • Arisawa Hiroki
    Department of Plastic and Reconstructive Surgery, Aichi Medical University Hospital
  • Ishikawa Saki
    Department of Plastic and Reconstructive Surgery, Aichi Medical University Hospital
  • Ito Yusuke
    Department of Plastic Surgery, Daiyukai Daiichi Hospital
  • Asai Akiko
    Department of Plastic and Reconstructive Surgery, Aichi Medical University Hospital
  • Yokoo Kazuhisa
    Department of Plastic Surgery, Daiyukai Daiichi Hospital
  • Furukawa Hiroshi
    Department of Plastic and Reconstructive Surgery, Aichi Medical University Hospital

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Other Title
  • 広範囲熱傷に対してbFGF徐放性人工真皮を使用したサンドウィッチ法の経験
  • －A Comparison with the Use of Cultured Epithelial Autografts（CEA）－
  • －自家培養表皮（Hybrid法）との比較－

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Abstract

 For extensive burns, the usual methods of treatment reported are those such as the Hybrid method, which combines Cultured Epithelial Autograft（CEA）and an autologous stratified skin graft, and the sandwich method, where an artificial dermis is attached on top of the meshed autografts.<br>  In this case, we used as an artificial dermal substitute, a collagen/gelatine scaffold with sustained release of basic Fibroblast Growth Factor（bFGF）for the sandwich method, and report the results in comparison with the Hybrid method.<br>  The hybrid method was used for most sites, but the sandwich method was performed on the section where CEA was insufficient.<br>  Engraftment was observed in both the sandwich method and the hybrid method, and epithelialization was completed at about the same time two weeks later.<br>  This skin grafting method has almost the same engraftment rate and time required for epithelialization compared to the sites where the Hybrid method was performed, and it can handle a larger variety of situations and treat burns at a lower medical cost. It is therefore considered to be a valuable treatment of extensive burns.

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