Alteration of expression of cyclophilin B in the rat chemical hepatocarcinogenesis
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- Hosoi Kazuhiro
- Department of Pharmacy, Hirosaki University Hospital
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- Terui Kazufumi
- Department of Pharmacy, Hirosaki University Hospital
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- Nakagawa Junichi
- Department of Pharmacy, Hirosaki University Hospital
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- Shimoyama Ritsuko
- Department of Pharmacy, Hirosaki University Hospital
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- Tsuyama Hiromasa
- Department of Pharmacy, Hirosaki University Hospital
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- Itagaki Shiro
- Department of Pharmacy, Hirosaki University Hospital
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- Tsuchida Shigeki
- Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine
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- Hayakari Makoto
- Department of Pharmacy, Hirosaki University Hospital Department of Pharmaceutical Sciences, Hirosaki University Graduate School of Medicine
Bibliographic Information
- Other Title
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- ラット肝化学発癌過程における cyclophilin B の発現変化
- ラット カン カガクハツガン カテイ ニ オケル cyclophilin B ノ ハツゲン ヘンカ
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Abstract
Altered expression of cyclophilin B (CyPB) in chemically induced hepatocarcinogenesis of rat, which was subjected to the Solt-Farber protocol, was analyzed by anti-N-terminal peptide antibody for CyPB. In a group of the partially hepatectomized rats after administration of diethylnitorsamine (DEN) interperitoneally followed by the oral administration of 2-acethylaminofluorene (FAA), marked induction of a tumor-specific marker GST-P and the formation of the precancerous lesion in rat liver were observed. A band of approximately 20 kDa molecular weight was detected by anti-N-terminal peptide antibody in the normal liver and testis. This band was estimated as a CyPB protein.The levels of CyPB in the precancerous lesion were increased from 1 week after hepatectomy, and the increase was approximately 2–fold up to 6 weeks. In addition, the levels of CyPB in serum were gradually increased from 4 to 7 week with delayed kinetics in the liver. The levels of CyPB were increased approximately 1.6-fold at the point of 7 week after the hepatectomy. These results suggested the possible role of CyPB as a tumor marker of the hepatocellular carcinoma.
Journal
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- Hirosaki Medical Journal
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Hirosaki Medical Journal 65 (2-4), 164-172, 2014
Hirosaki University Graduate School of Medicine,Hirosaki Medical Society
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Details 詳細情報について
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- CRID
- 1390288370502802176
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- NII Article ID
- 110009838256
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- NII Book ID
- AN00211444
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- ISSN
- 24344656
- 04391721
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- HANDLE
- 10129/5424
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- NDL BIB ID
- 025848444
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed