Hyperinsulinemia leads the elevation of plasma aldosterone concentration independently with obesity, dyslipidemia, and insulin resistance in patients with type 2 diabetes mellitus

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  • Kimura Yuki
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Matsui Jun
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Matsumura Koki
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Murakami Hiroshi
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Yamashita Maki
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Tanabe Jutaro
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Tamasawa Naoki
    Diabetes and Endocrinology, Aomori City Hospital
  • Daimon Makoto
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine

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Other Title
  • ２型糖尿病患者において高インスリン血症は肥満，脂質異常症，インスリン抵抗性とは独立して血漿アルドステロン濃度上昇に関与している

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Description

The study was to define plasma insulin level with the association of renin-angiotensin-aldosterone system activity in patients with type 2 diabetes. One hundred fifty type 2 diabetic patients and 24 non-diabetic subjects were studied. There was no statistical difference between the two groups in age, gender, the prevalence of hypertension, and serum potassium concentration. Plasma aldosterone concentration (PAC) was significantly higher in type 2 diabetics than that in non-diabetic subjects (10.4±4.9 vs. 7.4±3.7 ng/dl ; p=0.004) ; however plasma renin activity (PRA) did not differ significantly between the two groups. In diabetic patients, PAC correlated significantly with body mass index (BMI), fasting plasma insulin (F-IRI), homeostasis model assessment insulin resistance (HOMA-R), urinary C-peptide excretion (U-CPR), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). PRA correlated significantly with F-IRI and HOMA-R, but did not correlate with BMI, U-CPR, TG, and HDL-C. The additional contribution of U-CPR in predicting PAC was significant after adjustment for age, BMI, F-IRI, TG, HDL-C, and PRA (β=0.204, p=0.016). These findings indicate that hyperinsulinemia may affect the increase in PAC unrelated with obesity, dyslipidemia, insulin resistance that are components of metabolic syndrome in patients with type 2 diabetes.

Journal

  • Hirosaki Medical Journal

    Hirosaki Medical Journal 65 (1), 35-42, 2014

    Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

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