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Profiling of rat brain peptides treated with centrally active ace inhibitor

DOI IR

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Other Title
  • 中枢移行性アンジオテンシン変換酵素阻害剤投与によるラット脳内ペプチド性物質のプロファイリング
  • チュウスウ イコウセイ アンジオテンシン ヘンカン コウソ ソガイザイ トウヨ ニ ヨル ラット ノウナイ ペプチドセイ ブッシツ ノ プロファイリング

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Abstract

    This study is to be clarified the mechanism(s) of memory improvement by centrally active ACE inhibitor, captopril. We measured the expressed peptides in the rat brain treated with centrally active ACEI (captopril), non-centrally active ACEI (imidapril) and ARB (losartan) by HPLC and TOF-MS. As the result, we detected a large number of substances, which highly expressed in rat brain treated with captopril, by the TOF-MS technique. Molecular mass (m/z) of most of the all substances was less than 3,000. Since all mass number was confirmed as monovalent ions, these values reflected in the mass number derived from the unique substance and were completely different from mass numbers of endogenous substrates, such as LH-RH, substance P, β-neoendorphin, neuromedin B, LVV-hemorphin-7, and amyloid β-protein, which are cleaved by ACE, and vasopressin, which is thought as a substrate for IRAP in brain. However, many Zn²⁺-containing metalloproteases are present in rat brain. There might be those metalloproteases were inhibited by captopril that could form a chelate to the Zn²⁺ in the active center of enzyme. The many mass numbers obtained in this study can be also endogenous substrates for these metalloproteases.

Journal

  • Hirosaki Medical Journal

    Hirosaki Medical Journal 65 (1), 95-103, 2014

    Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

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