Treatment outcome of latent tuberculosis infection in persons with fibrotic pulmonary lesions
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- KOMUKAI Jun
- Osaka City Public Health Office
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- MATSUMOTO Kenji
- Otemae University
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- KUDOH Shinzoh
- Osaka Social Medical Center
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- OKADO Akihiro
- The Research Institute of Tuberculosis, Japan Anti-tuberculosis Association
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- YOSHIYAMA Takashi
- The Research Institute of Tuberculosis, Japan Anti-tuberculosis Association
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- YOSHIDA Hideki
- Osaka City Public Health Office
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- SHIMOUCHI Akira
- The Research Institute of Tuberculosis, Japan Anti-tuberculosis Association Osaka City Nishinari Ward
Bibliographic Information
- Other Title
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- 未治療陳旧性肺結核の潜在性結核感染症治療成績
- ミチリョウチンキュウ セイ ハイケッカク ノ センザイセイ ケッカク カンセンショウ チリョウ セイセキ
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Abstract
<p>Objective This study aimed to evaluate the treatment outcome of latent tuberculosis infection (LTBI) in persons with fibrotic pulmonary lesions, treated with isoniazid (INH) or rifampicin (RFP) in Nishinari Ward, Osaka City.</p><p>Methods As part of a tuberculosis screening program by chest X-ray (CXR), we selected persons who met the following four criteria for initiation of LTBI treatment:</p><p>①Anti-tuberculosis treatment has not been performed for more than one month in the past. </p><p>②CXR shows fibrotic pulmonary lesions.</p><p>③Fibrotic pulmonary lesions with CXR have not changed for more than one year.</p><p>④QuantiFERON TB Gold-in-tube (QFT) shows positive values (≥0.35 IU/mL).</p><p> Before treatment, the blood samples were within the standard values for aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and serum creatinine. Treatment with INH was stopped when AST or ALT levels were elevated to more than 150 IU/L, or symptoms of liver dysfunction appeared even when AST or ALT levels were less than 150 IU/L. After liver dysfunction improved, treatment with RFP was started.</p><p> Treatment completion was defined as being dispensed with INH for ≥180 days or RFP for ≥120 days.</p><p>Results The 27 participants were all male and their age was 68.4±6.6 years. Of the 27 participants, 14 (51.9%) completed treatment with INH. Of the remaining 13 persons, nine (69.2%) stopped treatment with INH because of liver dysfunction. Nine restarted RFP treatment and all participants completed the treatment without interruption by liver dysfunction. In total, 23 (85.2%) completed the treatment.</p><p>Conclusion LTBI treatment with INH in persons with fibrotic pulmonary lesions in the area where people in financial need live was stopped because of liver dysfunction; however, changes from INH to RFP could improve treatment outcomes.</p>
Journal
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- Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)
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Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) 68 (6), 405-411, 2021-06-15
Japanese Society of Public Health
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Keywords
Details 詳細情報について
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- CRID
- 1390288480070674944
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- NII Article ID
- 130008057177
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- NII Book ID
- AN00189323
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- ISSN
- 21878986
- 05461766
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- NDL BIB ID
- 031519429
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- PubMed
- 33790095
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed