Impact of Percutaneous Edge-to-Edge Repair in Patients With Atrial Functional Mitral Regurgitation
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- Yoshida Jun
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Ikenaga Hiroki
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Nagaura Takafumi
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Utsunomiya Hiroto
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Kawai Makoto
- Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine
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- Makar Moody
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Rader Florian
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Siegel Robert J.
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Kar Saibal
- Los Robles Regional Medical Center
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- Makkar Raj R.
- Smidt Heart Institute, Cedars-Sinai Medical Center
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- Shiota Takahiro
- Smidt Heart Institute, Cedars-Sinai Medical Center
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<p>Background:The aim of this study was to clarify the clinical outcomes of patients with atrial functional mitral regurgitation (FMR) who underwent the MitraClip procedure compared with those with conventional FMR and sinus rhythm (SR).</p><p>Methods and Results:Of 303 patients with FMR who underwent the MitraClip procedure, 40 with “atrial-FMR” defined as FMR with permanent atrial fibrillation and normal left ventricular (LV) function/size and 115 with “sinus-FMR” defined as FMR with SR and LV dysfunction were reviewed. Transthoracic and 3D transesophageal echocardiography, and the cardiac complication rate (composite of all-cause death, heart failure admission, mitral valve (MV) surgery, and redo MitraClip procedure) during the 12-month follow-up were compared between the groups. After the MitraClip procedure, reductions in the mitral annular area and its anteroposterior dimension and in the leaflet closure area were observed in both groups. MV orifice area was smaller with greater transmitral pressure gradient (P<0.05) after the procedure in atrial-FMR patients than in those with sinus-FMR. The prevalence of residual MR was similar, but significant tricuspid regurgitation (TR) was more prevalent in the atrial-FMR group at follow-up. Cardiac complication rate was comparable between groups (20% vs. 25%, P=0.63).</p><p>Conclusions:Reduction of MR occurred in atrial-FMR probably because of the increase in leaflet coaptation area. Significant TR was more common after the MitraClip procedure in patients with atrial-FMR than with sinus-FMR. However, mid-term outcomes were comparable between patients with atrial-FMR and sinus-FMR.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 85 (7), 1001-1010, 2021-06-25
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390288480070893056
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- NII論文ID
- 130008056919
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 031532191
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- PubMed
- 33612563
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可