Provisional Clinical Opinions for Radiation Therapy in Prefrail Elderly Colorectal Cancer Patients: Part One

  • Murofushi Keiko
    Division of Radiation Oncology, Department of Radiology,Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital
  • Murakami Yuji
    Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Makishima Hirokazu
    National Institute for Quantum and Radiological Science and Technology
  • Moriwaki Toshikazu
    Department of Gastroenterology, University of Tsukuba
  • Sasaki Takeshi
    Department of Colorectal Surgery, National Cancer Center Hospital East
  • Nakamura Masaki
    Department of Radiation Oncology, National Cancer Center Hospital East
  • Fukumitsu Nobuyoshi
    Department of Radiation Oncology, Kobe Proton Center
  • Zenda Sadamoto
    Department of Radiation Oncology, National Cancer Center Hospital East
  • Karasawa Kumiko
    Department of Radiation Oncology, School of Medicine, Tokyo Women's Medical University

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Other Title
  • 「プレフレイル高齢大腸がん患者のための臨床的提言」放射線治療に関する提言 Part I:Clinical Question 1~5

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Abstract

<p>The number of elderly cancer patients has been increasing for the past several decades in Japan. The selection of appropriate treatment for elderly patients with cancer is sometimes difficult because of their diverse characteristics and individual differences. In particular, for prefrail cancer patients, who are between fit and frail, the experience of medical staff affects the selection of treatment. Therefore, 10 clinical questions (CQs) have been suggested as provisional clinical opinions for radiotherapy in prefrail elderly colorectal cancer patients by the Radiation Therapy Working Group, comprising seven radiation oncologists, one gastroenterologist, and one gastroenterological surgeon. The present report examines CQ 1-5 as follows. CQ1: “What are the difficulties of radiotherapy for prefrail elderly patients with colorectal cancer?”; CQ2: “What is the branching point between standard treatment and reduced-intensity treatment with radiotherapy in prefrail elderly patients with colorectal cancer?”; CQ3: “What is the appropriate comprehensive geriatric assessment for elderly cancer patients to be treated with radiotherapy?”; CQ4: “What should be noted about the adverse events caused by radiotherapy in prefrail elderly patients with colorectal cancer?” and CQ5: “What should be noted about the adverse events caused by preoperative chemoradiation therapy in prefrail elderly patients with locally advanced rectal cancer?”</p>

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