Developmental Change of Hematological Features of the Anemic CFO Mouse (<i>heal</i> hea) with Hereditary Congenital Erythroblastic Anemia

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  • Developmental Change of Hematological Features of the Anemic CFO Mouse (heal hea) with Hereditary Congenital Erythroblastic Anemia

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ABSTRACT Developmental changes of hematological features of anemic CFO mice (heulheu) were studied in comparison with those of normal mice (+I+ or heal+). Anemia of newborn heu/heu mice was not severe, but was easily distinguishable from normal littermates by their yellow body color and also by their blood smear pictures which showed abundant erythroblasts. This disease proceeded rather progressively though many died around 10 days after birth and none survived after aged 25 days. Erythrocyte count, hematocrit percentage and hemoglobin content of heu/hea mice became to be nearly 50% of those of normals during development. On the other hand, leukocyte number of heu/heu mice was 3 to 8 times as many as that of normals. Although hepatomegaly was not evident, splenomegaly was remarkable in heulheu mice after aged 15 days: Platelet number of heulheu'was about 3 times as many as that of normals. On the contrary, megakaryocytes in the bone marrow of heu/heu mice were much fewer than those of normals. Nucleated cells, mainly orthochromatophilic erythroblasts, in the circulation of heu/hea mice were strikingly 80 to 100 times as many as those of normals. This progressively developed anemia caused by heu seemingly affected the differentiation of erythroid cells, but also that of myeloid cells and that of megakaryocytes.

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