Sodium Valproate-lnduced Cardiovascular Abnormalities in the JchlCR Mouse Fetus

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  • Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus
  • Sodium valproate induced cardiovascular
  • Sodium Valproate‐lnduced Cardiovascular Abnormalities in the JchlCR Mouse Fetus

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ABSTRACT Sodium valproate was administered to Jc1:ICR mice in order to evaluate teratogenicity in the cardiovascular system. A single dose of 600 mg/kg of sodium valproate was injected intraperitoneally on gestational day 6, 7, 8 or 9. On day 18 of gestation, dams were laparotomized to observe incidence and type of cardiovascular abnormality in live fetuses. Cardiovascular abnormalities were found most frequently in the group treated on day 7, being recognized in 86% of litters (19/22) and in 29% of live fetuses (70/238). Among these, there were 28 cases of transposition of the great arteries, 13 of double outlet right ventricle, 11 of endocardial cushion defect, 9 of ventricular septa1 defect, 5 of tricuspid atresia, and 4 of hypoplastic left heart syndrome.

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