Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection: Pathogenesis of Hydrocephalus Caused by Mumps Virus

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  • Experimental hydrocephalus in suckling hamster induced by myxovirus infection-1-Pathogenesis of hydrocephalus caused by mumps virus
  • Experimental hydrocephalus in suckling
  • Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection
  • Experimental hydrocephalus in suckling hamsters induced by myxovirus infection: pathogenesis of hydrocephalus caused by mumps virus

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ABSTRACT This study was undertaken to elucidate the pathogenesis of the hydrocepha- lus and aqueductal stenosis induced by intracerebral mumps virus inoculation in suck- ling hamsters. Mild ventricular dilatation became apparent after 5 days of inoculation. Focal denuding of the ependymal layer and subsequent aqueductal stenosis were observed by 14 days after inoculation. The virus antigen was detected not only in the ependymal cells and choroid plexus, but also in some neurons in the cerebral cortex, hippocampus, midbrain and cerebellum. In the cerebral aqueduct, the orderly arrangement of the cilialy clusters was destroyed on the 5th day after inoculation. After 10 days, proliferation of GFAP positive cells was noticed around the cerebral aqueduct and subsequently caused aqueductal stenosis. In the advanced state of hydrocephalus, the cerebellum was displaced down- ward and showed an elongated, atrophic and sleevelike structure similar to the Arnold-Chiari malformation. It was suggested that the extensive damage of the ependymal cilia may account for early ventricular dilatation, and subsequent aqueductal stenosis with glial proliferation is the main cause of the advanced hydrocephalus. It has not yet been determined whether the mumps virus can pass through the human placenta or not. If it can, however, our results strongly suggest that mumps virus infection in the human fetus will cause congenital hydrocephalus.

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